Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties
نویسندگان
چکیده
منابع مشابه
Preparation of hydrogel substrates with tunable mechanical properties.
The modulus of elasticity of the extracellular matrix (ECM), often referred to in a biological context as "stiffness," naturally varies within the body, e.g., hard bones and soft tissue. Moreover, it has been found to have a profound effect on the behavior of anchorage-dependent cells. The fabrication of matrix substrates with a defined modulus of elasticity can be a useful technique to study t...
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Herein, we report on the synthesis and characterization of enzymatically labile polyureas for use as a tissue-engineered ligament scaffold. Polyureas were selected due to their excellent tensile properties, fatigue resistance, and highly tunable nature. Incorporation of a collagenase-sensitive peptide into the backbone of the polyurea provided a means to confer cell-responsive degradation to th...
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The goal of this work was to utilize the naturally derived bioactive polymer hyaluronic acid (HA) to create a combination tissue engineering scaffold and protein delivery device. HA is a non-immunogenic, non-adhesive glycosaminoglycan that plays significant roles in several cellular processes, including angiogenesis and the regulation of inflammation. In previous work, we created photopolymeriz...
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Degradable polymers are beginning to play an increasing role as materials for environmental and medical applications. Understanding factors that control erosion, such as bond cleavage and the dissolution and diffusion of degradation products, will be critical to the future development of these materials. Erosion kinetics, photomicroscopy, and infrared spectroscopy were used to understand the er...
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Degradation or polyethylene glycol has been studi ed by UV irradiation. A drastic change in the morphology from spherulite to rhythmic pattern has been observed under polarized light microscope when exposed to UV light. Molecular weight of PEG. Rr value and melting point have been recorded after UV exposure. On UV exposure there has also been a change in UV. IR and powder X-ray diffraction patt...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2010
ISSN: 1525-7797,1526-4602
DOI: 10.1021/bm100137q